Estimated occurrenceUncommon diagnosis. Thirteen known cases in Sweden (2004).
CauseUnknown. Genetically determined. Changes have been found in six chromosomes with different mutations in different families. Laurence-Moon-Bardet-Biedl syndrome (LMBB) is an autosomal recessive disorder.
General symptomsSymptoms may vary but the core symptoms are retinal changes, extra fingers and/or toes, obesity, underdevelopment of the male reproductive organs (hypogenitalism) and low concentrations of sexual hormones (hypogonadism), renal changes, intellectual disability and coordination difficulties.
SynonymsBardet-Biedl syndrome, Laurence-Moon syndrome
Orofacial/odontological symptomsTooth anomalies may occur, such as lack of tooth buds for one or more teeth (hypodontia), small/thin teeth and short tooth roots. Snoring is common. Impaired oral motor function occurs and may cause speech and eating difficulties, as well as drooling.
Advice on follow-up and treatment
- Early contact with dental services for intensified prophylactic care and oral hygiene information is essential.
- Regular check-ups of dental and jaw development. Orthodontist should be consulted when needed.
- Extra care is recommended in orthodontic treatment of patients with short tooth roots.
- Snoring problems should be investigated by a physician in cases of suspected sleep apnea (frequent breathing pauses during sleep).
- Oral motor training may be required in cases of eating difficulties, speech impairment and drooling.
Updated: 2019-11-12 14:53