Marker chromosome 15 syndrome
Codes
ICD-10: Q99.8
ORPHA: 3306
General information
Estimated occurrence
3:100,000 live births.Cause
These children are born with an extra chromosome, a so-called marker chromosome, which contains genetic material from chromosome 15.
General symptoms: People with marker chromosome 15 syndrome often have intellectual disabilities, low muscle tension, poor locomotor development, autism spectrum disorder and sometimes epilepsy. Many of those affected have stomach and intestinal disorders.
General symptoms
People with marker chromosome 15 syndrome often have intellectual disabilities, low muscle tension, poor locomotor development, autism spectrum disorder and sometimes epilepsy. Many of those affected have stomach and intestinal disorders.
Synonyms
Idic (15) syndrome, Isodicentric 15 syndrome.
Orofacial/odontological symptoms
There may be some common characteristics in the diagnosis. Many children with this syndrome find it difficult to accept dental treatment and brush their teeth. Some medicines may produce side effects in the form of a dry mouth, which can increase the risk of tooth decay. Problems with sucking, eating and swallowing occur mainly during infancy. Speech, language and communication difficulties are common.
Advice on follow-up and treatment
- Early contact with dental services for intensified prophylactic care and oral hygiene information is essential for people with Marker chromosome 15 syndrome.
- Training in oral motor skills and extra stimulation in cases of eating disorders, speech difficulties and impaired saliva control may be necessary.
- Feeding and swallowing difficulties are investigated and treated by a specialist team at the hospital or multidisciplinary treatment centre.
- Speech, language and communication training is important.
Sources
National Board of Health and Welfare
